Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain
Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain
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DOI：
10.1016/j.tox.2011.04.005
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发表时间：
2011-07-11
期刊：
影响因子：
4.5
通讯作者：
Nakamura, Shoji
中科院分区：
文献类型：
--
作者：
Mohideen, Sahabudeen Sheik;Ichihara, Gaku;Nakamura, Shoji
1-溴丙烷（1-BP）已被用作臭氧消耗溶剂的替代品。先前的研究表明，1-BP对动物和人类具有神经毒性。在人类中，暴露于1-BP会引起各种神经和神经行为症状或体征，包括抑郁或烦躁情绪。然而，1-BP引起的抑郁症状的神经生物学变化仍有待确定。抑郁症状被认为与含有去甲肾上腺素和血清素的轴突变性有关。基于这一假设，本研究探讨了重复暴露于1-BP对肾上腺素能和去甲肾上腺素能轴突的影响。暴露于1-BP诱导大鼠前额叶皮质去甲肾上腺素能轴突密度呈剂量依赖性降低，但肾上腺素能轴突密度无明显变化。结果表明，抑郁症状的工人暴露于I-BP是由于，至少部分，在大脑中的去甲肾上腺素能轴突的变性。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
1-Bromopropane (1-BP) has been used as an alternative to ozone-depleting solvents. Previous studies showed that 1-BP is neurotoxic in animals and humans. In humans, exposure to 1-BP caused various neurological and neurobehavioral symptoms or signs including depressive or irritated mood. However, the neurobiological changes underlying the depressive symptoms induced by 1-BP remain to be determined. The depressive symptoms are thought to be associated with degeneration of axons containing noradrenaline and serotonin. Based on this hypothesis, the present study examined the effects of repeated exposure to 1-BP on serotonergic and noradrenergic axons. Exposure to 1-BP induced dose-dependent decreases in the density of noradrenergic axons in the rat prefrontal cortex, but no apparent change in the density of serotonergic axons. The results suggest that depressive symptoms in workers exposed to I-BP are due, at least in part, to the degeneration of noradrenergic axons in the brain. (C) 2011 Elsevier Ireland Ltd. All rights reserved.