Short Communication: HIV-1 Infection Suppresses Circulating Viral Restriction microRNAs.
Short Communication: HIV-1 Infection Suppresses Circulating Viral Restriction microRNAs.
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DOI：
10.1089/aid.2015.0253
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发表时间：
2016-03
影响因子：
1.5
通讯作者：
Yu Zhou;Li Sun;Xu Wang;Hao Liang;L. Ye;Li Zhou;B. Liang;Jieliang Li;Manqing Liu;J. Peng;D. Zhou;X. Gui;W. Ho
中科院分区：
文献类型：
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作者：
Yu Zhou;Li Sun;Xu Wang;Hao Liang;L. Ye;Li Zhou;B. Liang;Jieliang Li;Manqing Liu;J. Peng;D. Zhou;X. Gui;W. Ho
MicroRNA（miRNAs）参与宿主抗HIV-1感染的先天免疫。我们研究了HIV-1感染对HIV-1感染受试者血浆中病毒限制性miRNA的影响。HIV-1感染受试者的HIV-1限制性miRNA（miR-29 a、-29 b、-125 b、-223、-198和-382）血浆水平显著低于对照受试者。进一步的体外研究表明，巨噬细胞的HIV-1感染抑制了细胞外miR-29 b、-125 b和-223的产生。这些数据证明了HIV-1感染通过抑制抗病毒miRNA而损害宿主先天免疫的令人信服的证据，这为HIV-1在宿主中的持续存在提供了可能的机制。
MicroRNAs (miRNAs) participate in host innate immunity against HIV-1 infection. We examined the impact of HIV-1 infection on viral restriction miRNAs in plasma of HIV-1-infected subjects. HIV-1-infected subjects had significantly lower plasma levels of HIV-1 restriction miRNAs (miRs-29a, -29b, -125b, -223, -198, and -382) than control subjects. Further in vitro studies showed that HIV-1 infection of macrophages suppressed production of the extracellular miRs-29b, -125b, and -223. These data demonstrate the compelling evidence that HIV-1 infection impairs host innate immunity by inhibiting antiviral miRNAs, which provide a possible mechanism for HIV-1 persistence in the host.