Wireless transmission of voltage transients from a chronically implanted neural stimulation device
Wireless transmission of voltage transients from a chronically implanted neural stimulation device
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DOI：
10.1088/1741-2552/ac63ea
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发表时间：
2022-04-01
影响因子：
4
通讯作者：
Cogan, Stuart F.
中科院分区：
文献类型：
--
作者：
Frederick, Rebecca A.;Troyk, Philip R.;Cogan, Stuart F.
Objective.来自无线神经设备的数据的一致传输对于监测刺激电极的状况和性能至关重要。迄今为止，没有无线神经接口已经证明能够通过无线数据传输监测长期植入电极的完整性。Approach.在这项工作中，我们提出了一种方法，用于无线记录的电压瞬态（VT）响应恒流，阴极第一不对称脉冲从微电极阵列。我们在大鼠坐骨神经中植入了六个无线设备，并在38周的植入期内无线记录了VT测量值。主要结果。在整个38周研究期间，电极最大阴极电位偏移（E-mc）、接入电压和驱动电压（从每个VT中提取）保持稳定。在植入后第1周，响应于4.7 μ A、200.2 μ s脉冲的平均E-mc（来自施加的+0.6 V脉冲间偏压）为267 +/- 107 mV，在植入后第38周为282 +/- 52 mV。相同4.7 μ A脉冲幅度的通路电压在植入后第1周为239 +/- 65 mV，在植入后第38周为268 +/- 139 mV。意义通过反向遥测从无线微电极阵列记录的VT反应在38周植入期内没有显著变化，并且与先前报告的具有相同几何形状的有线微电极的VT相似。此外，器械植入前后在磷酸盐缓冲盐水中无线记录的VT响应与预期一致，显示出比体内VT响应显著更小的电极极化和更小的接入电压。
Objective. Consistent transmission of data from wireless neural devices is critical for monitoring the condition and performance of stimulation electrodes. To date, no wireless neural interface has demonstrated the ability to monitor the integrity of chronically implanted electrodes through wireless data transmission. Approach. In this work, we present a method for wirelessly recording the voltage transient (VT) response to constant-current, cathodic-first asymmetric pulsing from a microelectrode array. We implanted six wireless devices in rat sciatic nerve and wirelessly recorded VT measurements throughout a 38 week implantation period. Main results. Electrode maximum cathodic potential excursion (E-mc), access voltage, and driving voltage (extracted from each VT) remained stable throughout the 38 week study period. Average E-mc (from an applied +0.6 V interpulse bias) in response to 4.7 mu A, 200.2 mu s pulses was 267 +/- 107 mV at week 1 post-implantation and 282 +/- 52 mV at week 38 post-implantation. Access voltage for the same 4.7 mu A pulsing amplitude was 239 +/- 65 mV at week 1 post-implantation and 268 +/- 139 mV at week 38 post-implantation. Significance. The VT response recorded via reverse telemetry from the wireless microelectrode array did not significantly change over a 38 week implantation period and was similar to previously reported VTs from wired microelectrodes with the same geometry. Additionally, the VT response recorded wirelessly in phosphate buffered saline before and after device implantation appeared as expected, showing significantly less electrode polarization and smaller access voltage than the VT response in vivo.