Early-onset breast cancer - Histopathological and prognostic considerations
Early-onset breast cancer - Histopathological and prognostic considerations
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DOI：
10.1038/bjc.1997.223
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发表时间：
1997-05-01
影响因子：
8.8
通讯作者：
Blamey, RW
中科院分区：
文献类型：
--
作者：
Kollias, J;Elston, CW;Blamey, RW
在乳腺癌的自然病史中，年轻的诊断年龄被认为是一个预后因素。1973年至1993年间，在诺丁汉城市医院接受原发性可手术乳腺癌（直径< 5 cm）治疗的2879例年龄小于或等于70岁的患者中，120例诊断时年龄小于35岁。比较了年龄< 35岁、35-50岁和51-70岁患者的组织学和预后变量。与两个年龄较大的年龄组相比，年龄< 35岁的乳腺癌患者的无转移生存率和精算生存率显著降低。诊断时年龄< 35岁的患者更常出现高级别癌症和血管浸润。肿瘤大小或淋巴结分期无差异。使用诺丁汉预后指数（NPI）对每个年龄组的癌症进行分层。由于倾向于高级别，年龄< 35岁的患者中有更大比例的患者进入预后不良组。在每个预后组中，年龄组之间的精算生存率没有差异。在这一系列中，诊断时年龄较小与预后较差的相关性可以通过低分化癌症的比例较高来解释;年龄本身对个体的预后没有影响。
Young age at diagnosis is claimed to be a prognostic factor in the natural history of breast cancer. Of 2879 patients aged less than or equal to 70 years treated for primary operable breast cancer (< 5 cm diameter) at Nottingham City Hospital between 1973 and 1993, 120 were less than 35 years of age at diagnosis. Histopathological and prognostic variables were compared between patients aged < 35, 35-50 and 51-70 years. A significant reduction in metastasis disease-free survival and actuarial survival was seen in breast cancer patients aged < 35 years compared with the two older age groups. Patients aged < 35 years at diagnosis presented more frequently with high-grade cancers and vascular invasion. No differences were seen for tumour size or lymph node stage. The Nottingham Prognostic Index (NPI) was used to stratify cancers in each age group. Because of the tendency to high grade, a greater percentage of patients aged < 35 years tell into the poor-prognosis group. Within each prognostic group, no difference in actuarial survival was seen between age groups. The association of young age at diagnosis with a worse prognosis in this series is explained by a higher proportion of poorly differentiated cancers; age itself had no influence on the prognosis of the individual.