Experimental syphilis: guinea pig model.
Experimental syphilis: guinea pig model.
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实验梅毒：豚鼠模型。
DOI：
10.1136/sti.59.3.157
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
S. Nakeeb
中科院分区：
文献类型：
--
作者：
C. Pierce;K. Wicher;S. Nakeeb
用不同浓度的梅毒螺旋体Nichols菌株在耻骨区皮内感染远系杂交的Hartley雄性豚鼠（300-400 g）。半数致死剂量（ID 50）约为10（5）。动物产生暗视野显微镜可见的病变、密螺旋体抗体（仅IgG）和淋巴器官的组织病理学变化。虽然当感染足够数量的微生物时，豚鼠对梅毒螺旋体感染的敏感性低于兔，但豚鼠可能是实验梅毒的有用模型。
Outbred Hartley male guinea pigs (300-400 g) were infected intradermally with various concentrations of Treponema pallidum Nichols strain in the pubic region. The median lethal dose (ID50) was approximately 10(5). The animals produced lesions visible by darkfield microscopy, treponemal antibodies (IgG only), and histopathological changes in the lymphoid organs. Though less susceptible to T pallidum infection than the rabbit when infected with a sufficient number of organisms, the guinea pig may be a useful model in experimental syphilis.