Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents.
Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents.
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DOI：
10.1016/j.ejmech.2010.05.040
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发表时间：
2010-09
影响因子：
6.7
通讯作者：
Zhang, Yongshen
中科院分区：
文献类型：
--
作者：
Zhu, Shuren;Wang, Joe;Chandrashekar, Gudise;Smith, Erika;Liu, Xianjun;Zhang, Yongshen
Febrifugine is an alkaloid isolated from Dichroa febrifuga as the active component against Plasmodium falciparum. Adverse side effects have precluded febrifugine as a potential clinical drug. As part of an ongoing malaria chemotherapy project, novel febrifugine analogues were designed and synthesized. Lower toxicity of these newly designed compounds was achieved by reducing or eliminating the tendency to form chemically reactive and toxic intermediates. New compounds possess excellent in vivo antimalarial activity and most of them become less toxic than the natural product febrifugine. Some of the compounds possess a therapeutic index over ten times superior to that of febrifugine and the commonly used antimalarial drug chloroquine. These compounds, as well as the underlying design rationale, may find usefulness in the discovery and development of new antimalarial drugs.
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影响因子：
7.3
作者：
CHIEN, PL;CHENG, CC
通讯作者：
CHENG, CC
影响因子：
7.3
作者：
Takaya, Y;Tasaka, H;Oshima, Y
通讯作者：
Oshima, Y
影响因子：
5.2
作者：
Taniguchi, T;Ogasawara, K
通讯作者：
Ogasawara, K
影响因子：
4.9
作者：
Jiang, SP;Zeng, Q;Fang, DH
通讯作者：
Fang, DH
DOI：
10.4269/ajtmh.1952.1.768
发表时间：
1952-01-01
影响因子：
3.3
作者：
HEWITT, RI;WALLACE, WS;WILLIAMS, JH
通讯作者：
WILLIAMS, JH