MEASLES-VIRUS INFECTION OF CEREBRAL ENDOTHELIAL-CELLS AND EFFECT ON THEIR ADHESIVE PROPERTIES
MEASLES-VIRUS INFECTION OF CEREBRAL ENDOTHELIAL-CELLS AND EFFECT ON THEIR ADHESIVE PROPERTIES
复制标题
DOI：
10.1016/0378-1135(95)00006-v
复制
发表时间：
1995-05-01
影响因子：
3.3
通讯作者：
BRANKIN, B
中科院分区：
文献类型：
--
作者：
COSBY, SL;BRANKIN, B
亚急性硬化性泛脑炎(SSPE)患者脑组织内皮细胞(EC)中存在麻疹病毒(MV)RNA，体外培养的人脑EC产生较高滴度的传染性病毒。因此，EC在血脑屏障的感染可能为病毒进入中枢神经系统提供机会。同种异体脾细胞与MV感染的小鼠(Balb/c)脑内皮细胞的黏附被发现上调。病毒感染后血脑屏障内皮细胞黏附分子表达增加可能是SSPE中枢神经系统炎症浸润的重要机制。
Measles virus (MV) RNA is present in endothelial cells (Ec) in brain tissue from cases of subacute sclerosing panencephalitis (SSPE) and relatively high titres of infectious virus are produced in human cerebral Ec in vitro. Infection of Ec at the blood-brain barrier could therefore provide the opportunity for entry of virus to the CNS. Adhesion of syngeneic splenocytes to MV infected murine (Balb/c) cerebral Ec is found to be upregulated. Increased expression of endothelial adhesion molecules, following virus infection at the blood-brain-barrier, may be an important mechanism in inducing inflammatory infiltration of the CNS in SSPE.