Pulmonary resident neutrophils regulate the production of GM‐CSF and alveolar macrophages
Pulmonary resident neutrophils regulate the production of GM‐CSF and alveolar macrophages
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DOI：
10.1111/febs.13684
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
F. Tian;Yong Han;Jian Song;J. Lei;Xiaolong Yan;Nianlin Xie;Jian Wang;Jinbo Zhao;Xiaohua Liang;D. Zhong;Yong’an Zhou;Xiaoping Wang;Xiaofei Li
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文献类型：
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作者：
F. Tian;Yong Han;Jian Song;J. Lei;Xiaolong Yan;Nianlin Xie;Jian Wang;Jinbo Zhao;Xiaohua Liang;D. Zhong;Yong’an Zhou;Xiaoping Wang;Xiaofei Li
肺泡巨噬细胞存在于肺间隙中，其分化和功能受微环境的调控。在这项研究中，我们研究了常驻中性粒细胞/IL - 23/粒细胞/巨噬细胞集落刺激因子（GM - CSF）轴在生理条件下肺泡巨噬细胞的发育和优先表型中的重要作用。使用CD18 -缺陷（CD18−/−）小鼠，我们以IL - 23 -和GM - CSF依赖的方式显示颗粒生成增加和肺泡巨噬细胞发育增强之间的相关性。凋亡的中性粒细胞可以抑制肺泡巨噬细胞分泌IL - 23，而IL - 23对GM - CSF的产生是重要的，中性粒细胞的消耗破坏了IL - 23和GM - CSF的调节。本研究揭示了循环系统中嗜中性粒细胞凋亡调控局部肺泡巨噬细胞数量和功能的机制。
Alveolar macrophages exist in the lung airspaces, and their differentiation and function are considerably regulated by the microenvironment. In this study, we examine the important role of resident neutrophil/IL‐23/granulocyte/macrophage colony‐stimulating factor (GM‐CSF) axis in the development and preferential phenotype of alveolar macrophages under physiological conditions. Using CD18‐deficient (CD18−/−) mice, we show a correlation between increased granulopoiesis and enhanced alveolar macrophage development in an IL‐23‐ and GM‐CSF‐dependent manner. The apoptotic neutrophils could inhibit the secretion of IL‐23 from alveolar macrophages, which is important for the production of GM‐CSF, and depletion of neutrophils disrupted the regulation of IL‐23 and GM‐CSF. This study reveals a mechanism for the regulation of the local alveolar macrophage population and function by neutrophil apoptosis in the circulatory system.