A Survey of the Opinions of Transfusion Specialists on Transfusion Policy of Thalassemia Patients in Korea
A Survey of the Opinions of Transfusion Specialists on Transfusion Policy of Thalassemia Patients in Korea
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DOI：
10.17945/kjbt.2017.28.3.282
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Kim, HyungHoi
中科院分区：
文献类型：
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作者：
HYUN-JI, LEE;Shin, Kyung-Hwa;Kim, HyungHoi
背景：地中海贫血患者通过长期输血来缓解症状。近年来，随着东南亚国家移民人数的增加，韩国地中海贫血症的发病率不断上升。目前，与其他遗传性溶血性贫血一样，地中海贫血的输血政策尚无概述的输血指南。在此，我们调查了输血专家对韩国地中海贫血输血政策的看法。方法：2017年7月至9月进行电子邮件调查；共有40名在综合医院工作的检验医学专家和参与的输血医学专家被纳入其中。问卷内容包括地中海贫血患者的输血经历和输血政策。结果：最终有36人（90%）回答了问卷；其中，32人（88.9%）同意制定地中海贫血患者输血指南的必要性，2人（5.6%）有条件同意。 35 名 (97.2%) 受访者同意地中海贫血患者输血时需要延长红细胞抗原匹配。 35 名 (97.2%) 专家一致认为，需要对 ABO 和 RhD 以外的红细胞抗原进行扩展匹配，包括 C、c、E 和 e。结论：总而言之，韩国需要针对地中海贫血（包括其他遗传性溶血性贫血）的输血指南。在制定此类指南时应考虑红细胞抗原的扩展配型，至少Rh血型的C、c、D、E、e抗原是红细胞抗原的扩展配型所必需的。
Background: Thalassemia patients are treated with chronic blood transfusion to relief symptoms. The prevalence of thalassemia in Korea has been increasing recently in response to an increase in the number of immigrants from Southeast Asian countries. Currently, there is no guidelines of blood transfusion outlined by the policy of transfusion of thalassemia, like other inherited hemolytic anemia. Herein, we survey the opinion of transfusion specialists about the policy of blood transfusion of thalassemia in Korea.Methods: E-mail survey was conducted between July and September of 2017; a total of 40 laboratory medicine specialists working at a general hospital and participating transfusion medicine were included. The questionnaire consisted of blood transfusion experience and blood transfusion policy in patients with thalassemia.Results: Finally, 36 (90%) responders answered the questionnaire; of them, 32 (88.9%) agreed on the necessity of establishing a transfusion guideline for thalassemia patients, and 2 (5.6%) conditionally agreed. Thirty-five (97.2%) respondents agreed on the need for extended matching of RBC antigens for blood transfusion in patients with thalassemia. Thirty-five (97.2%) specialists agreed on the need for extended matching of RBC antigens beyond ABO and RhD to include C, c, E, and e.Conclusion: In conclusion, the transfusion guideline for thalassemia, including other inherited hemolytic anemia, is required in Korea. Extended matching of RBC antigens should be considered when developing such guidelines, at least C, c, D, E, e antigens of the Rh blood group are essential for extended matching of RBC antigens.