Association of CCR5 del32 with reduced risk of asthma

Association of CCR5 del32 with reduced risk of asthma
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DOI:
10.1016/s0140-6736(99)03425-x
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发表时间:
1999-10-09
期刊:
影响因子:
168.9
通讯作者:
Helms, PJ
Helms, PJ
中科院分区:
医学1区
文献类型:
--
作者:
Hall, IP;Wheatley, A;Helms, PJ

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我们报道了携带CCR 5 Delta 32突变(C-C趋化因子受体5(CCR 5)的一种天然变异体)的个体发生哮喘的风险降低。这些数据表明,这种突变在普通人群中的高患病率可能是一种解释。
We report that Individuals carrying the CCR5 Delta 32 mutation, a naturally occurring variant of the C-C chemokine receptor 5 (CCR5), are at reduced risk of developing asthma, These data suggest a possible explanation for the high prevalence of this mutation in the general population.