Efficacy of tracheal gas insufflation in spontaneously breathing sheep with lung injury
Efficacy of tracheal gas insufflation in spontaneously breathing sheep with lung injury
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DOI：
10.1164/ajrccm.159.3.9801126
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发表时间：
1999-03-01
影响因子：
24.7
通讯作者：
Kolobow, T
中科院分区：
文献类型：
--
作者：
Cereda, MF;Sparacino, ME;Kolobow, T
气管气体吹入（TGI）减少死腔（VD），并且可以与持续气道正压通气（CPAP）结合以减少每分钟通气量（VE）和呼吸努力。在11只麻醉绵羊上，通过油酸（OA）输注诱导急性肺损伤（ALI），研究了TGI联合CPAP（CPAP TGI）在不同TGI流量和不同导管设计下的作用。将绵羊随机分为两组：A组（n = 7）接受CPAP和CPAP-TGI，通过反向推力导管（RTC）以10和15 L/min的吹入流量输送。B组（n = 4）经RTC和直流导管（SFC）以10 L/min的流量进行CPAP和CPAP-TGI。与单独CPAP相比，CPAP TGI导致VD、VE、压力时间乘积和呼吸功显著降低。我们发现，与10 L/min相比，15 L/min的TGI流量没有额外的益处，SFC和RTC之间也没有统计学显著差异。结论：TGI可与CPAP联合应用，以减少肺通气量和呼吸努力。
Tracheal gas insufflation (TGI) decreases dead space (VD) and can be combined with continuous positive airway pressure (CPAP) to decrease minute volume (VE) and effort of breathing. In 11 anesthetized sheep, we induced acute lung injury (ALI) through oleic acid (OA) infusion and studied the effects of TGI combined with CPAP (CPAP-TGI) at different TGI flows and with catheters of different designs. Sheep were randomized to two groups: Group A (n = 7) was placed on CPAP and CPAP-TGI at 10 and 15 L/min of insufflation flow delivered through a reverse thrust catheter (RTC). Group B (n = 4) was placed on CPAP and CPAP-TGI at a flow of 10 L/min delivered through a RTC, and through a straight flow catheter (SFC). Compared with CPAP alone, CPAP-TGI resulted in significantly lower VD, VE, pressure time product, and work of breathing. We found no additional benefit from TGI flow of 15 L/min, compared with 10 L/min, and no statistically significant difference between the SFC and the RTC. In conclusion, TGI can be combined with CPAP in this model of ALI to reduce ventilation and effort of breathing.