Enhanced expression of vascular cell adhesion molecule-1 by corticotrophin-releasing hormone contributes to progression of atherosclerosis in LDL receptor-deficient mice
Enhanced expression of vascular cell adhesion molecule-1 by corticotrophin-releasing hormone contributes to progression of atherosclerosis in LDL receptor-deficient mice
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DOI：
10.1016/j.atherosclerosis.2008.05.059
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发表时间：
2009-04-01
期刊：
影响因子：
5.3
通讯作者：
Li, Shengnan
中科院分区：
文献类型：
--
作者：
Wu, Yuqing;Zhang, Rongjian;Li, Shengnan
外周产生的促肾上腺皮质激素释放激素(CRH)是一种强烈的促炎因子，与许多炎症性疾病有关。然而，到目前为止，还没有证据表明CRH在动脉粥样硬化中的作用，动脉粥样硬化是一种以炎症反应为特征的慢性疾病。在本研究中，我们观察了CRH对低密度脂蛋白受体缺陷(LDLR-/-)小鼠动脉粥样硬化的影响。12周龄雄性LDLR-/-小鼠皮下注射CRH(10µg/kg)或赋形剂，每日1次，连续8周。结果显示，主动脉粥样硬化病变范围较大(P
Peripherally produced corticotrophin-releasing hormone (CRH) is a strong proinflammatory factor involved in many inflammatory diseases. However, to date, there is no evidence about the action of CRH on atherosclerosis, a chronic disease characterized by inflammatory reactions. In this study we observed the effect of CRH on atherosclerosis in low-density lipoprotein receptor-deficient (LDLr-/-) mice. Twelve-week-old, male LDLr-/- mice were subcutaneously injected with CRH (10 mu g/kg) or vehicle once a day for 8 weeks. The results indicated aortic atherosclerotic lesions were larger (P