Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease.
Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease.
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DOI：
10.1111/aji.12083
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Burt TD
中科院分区：
文献类型：
--
作者：
Burt TD
发育中的胎儿必须主动学习耐受良性抗原，否则将承受耐受性破坏的后果。自身抗原的耐受性可防止自身免疫性疾病的发生，这是通过胸腺中自身反应性 T 细胞克隆的缺失（中枢耐受性）和外周 CD4+CD25+FoxP3+ 调节性 T 细胞 (Treg) 的抑制影响来实现的。胎儿 CD4+ T 细胞具有很强的分化成耐受性 Tregs 的倾向，这些 Tregs 会积极促进自我耐受，以及对大多数胎儿组织中嵌合母体细胞上的非遗传性抗原的耐受性。当胎儿接近出生时，耐受性胎儿免疫系统和能够对抗病原体的更具防御性的成人型免疫系统之间必须发生关键转变。本文将回顾人类胎儿免疫系统独特的耐受性，并将检验胎儿免疫发育新模型的证据：分层免疫系统假说。
The developing fetus must actively learn to tolerate benign antigens, or suffer the consequences of broken tolerance. Tolerance of self-antigens prevents development of autoimmune diseases, and is achieved by both deletion of autoreactive T cell clones in the thymus (central tolerance) and by the suppressive influence of CD4+CD25+FoxP3+ regulatory T cells (Tregs) in the periphery. Fetal CD4+ T cells have a strong predisposition to differentiate into tolerogenic Tregs that actively promote self-tolerance, as well as tolerance to non-inherited antigens on chimeric maternal cells that reside in most fetal tissues. As the fetus nears birth, a crucial transition must occur between the tolerogenic fetal immune system and a more defensive adult-type immune system that is able to combat pathogens. This paper will review the unique tolerogenic nature of the human fetal immune system and will examine evidence for a novel model of fetal immune development: the layered immune system hypothesis.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1126/science.1198469
发表时间：
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期刊：
Science (New York, N.Y.)
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DOI：
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发表时间：
2005-11-21
期刊：
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影响因子：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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