The caBIG® Life Sciences Distribution
The caBIG® Life Sciences Distribution
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DOI：
10.1007/978-1-4419-5714-6_14
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Komatsoulis, George
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文献类型：
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作者：
Klemm, Juli;Basu, Anand;Komatsoulis, George
caBIG (R) 是一个由开发和采用可互操作数据库和分析工具的组织组成的虚拟网络，旨在促进癌症转化研究（von Eschenbach 和 Buetow，2007 年）。它是一个开放源码、开放存取的计划，所有工具和资源都免费提供给研究界。美国国家癌症研究所正在开发资源，以帮助整个企业采用 caBIG (R) 工具。为此，我们将成熟的软件工具捆绑在一起，以方便采用和安装。生命科学分发版 (LSD) 由支持转化研究连续性的工具组成：caArray，用于管理和注释微阵列数据；caTissue，用于支持生物样本的收集、注释和分发；临床试验对象数据系统，用于共享临床试验信息；国家生物医学成像档案，用于注释、存储和共享活体图像；癌症全基因组关联研究，用于发布和挖掘来自 GWAS 研究的数据；geWorkbench，支持表达和序列数据的综合分析和注释。所有 LSD 工具都连接到 caGrid（Saltz 等人，2006 年），这使得多个机构的数据库可以相互连接，支持数据共享和整合。有关 LSD 产品套件的更多信息，包括安装包、用户和安装指南以及示例安装链接，请访问 http://ncicb.nci.nih.gov/NCICB/tools/lsd。
caBIG (R) is a virtual network of organizations developing and adopting interoperable databases and analytical tools to facilitate translational cancer research (von Eschenbach and Buetow 2007). It is an open-source, open-access program, and all the tools and resources are freely available to the research community. The National Cancer Institute is developing resources to assist enterprise-wide adoption of the caBIG (R) tools. To this end, we have bundled mature software tools together to facilitate easy adoption and installation. The Life Sciences Distribution (LSD) is comprised of tools to support the continuum of translational research: caArray, for the management and annotation of microarray data; caTissue, to support the collection, annotation, and distribution of biospecimens; the Clinical Trials Object Data System, for the sharing of clinical trials information; the National Biomedical Imaging Archive, for annotation, storage, and sharing of in vivo images; cancer Genome Wide Association Studies, for publishing and mining data from GWAS studies; and geWorkbench, supporting the integrated analysis and annotation of expression and sequence data. All the LSD tools are connected to caGrid (Saltz et al. 2006), which makes it possible for the databases at multiple institutions to be interconnected to support data sharing and integration.More information on the LSD suite of products, including installation packages, user and installation guides, and links to exemplar installations can be found at http://ncicb.nci.nih.gov/NCICB/tools/lsd.