Corticostriatal projections from rat barrel cortex have an anisotropic organization that correlates with vibrissal whisking behavior
Corticostriatal projections from rat barrel cortex have an anisotropic organization that correlates with vibrissal whisking behavior
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DOI：
10.1523/jneurosci.19-24-10908.1999
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发表时间：
1999-12-15
影响因子：
5.3
通讯作者：
Roy, SA
中科院分区：
文献类型：
--
作者：
Alloway, KD;Crist, J;Roy, SA
为了阐明从啮齿动物体感皮层皮质纹状体预测的详细组织，顺行示踪剂生物素化葡聚糖胺（BDA）和氟红宝石（FR）被注入到单独的部分的晶须“桶”表示。在一组大鼠中，将两种示踪剂注射到位于同一行的不同桶柱中;在另一组大鼠中，将示踪剂沉积到位于不同行的桶柱中。重建标记的轴突静脉曲张在新纹状体和丘脑腹侧进行了定量分析，比较重叠的预测，这些皮质下结构的程度。对于这两组动物，皮质纹状体的预测终止于密集的集群，占据弯曲的层状区域沿着背外侧边缘的新纹状体。当示踪剂被注入到不同的晶须桶行，BDA和FR标记的终端在新纹状体的分布遵循一个粗糙的躯体组织中的重叠量大致相同的腹侧丘脑。然而，当两种示踪剂被注入到相同的晶须桶行，皮质纹状体重叠的量显着高于在ventrobasal丘脑中观察到的重叠量。这些结果表明，从晶须桶皮质皮质皮质纹状体的预测有一个各向异性的组织，与在搅拌行为的触须运动的模式。
To elucidate the detailed organization of corticostriatal projections from rodent somatosensory cortex, the anterograde tracers biotinylated dextran amine (BDA) and fluoro-ruby (FR) were injected into separate parts of the whisker "barrel" representation. In one group of rats, the two tracers were injected into different barrel columns residing in the same row; in the other group of rats, the tracers were deposited into barrel columns residing in different rows. Reconstructions of labeled axonal varicosities in the neostriatum and ventrobasal thalamus were analyzed quantitatively to compare the extent of overlapping projections to these subcortical structures. For both groups of animals, corticostriatal projections terminated in densely packed clusters that occupied curved lamellar-shaped regions along the dorsolateral edge of the neostriatum. When the tracers were injected into different whisker barrel rows, the distribution of BDA- and FR-labeled terminals in the neostriatum followed a crude somatotopic organization in which the amount of overlap was approximately the same as in the ventrobasal thalamus. When both tracers were injected into the same whisker barrel row, however, the amount of corticostriatal overlap was significantly higher than the amount of overlap observed in the ventrobasal thalamus. These results indicate that corticostriatal projections from whisker barrel cortex have an anisotropic organization that correlates with the pattern of vibrissal movements during whisking behavior.