Infraslow EEG activity modulates cortical excitability in postanoxic encephalopathy.
Infraslow EEG activity modulates cortical excitability in postanoxic encephalopathy.
复制标题
下慢脑电图活动调节缺氧后脑病的皮质兴奋性。
DOI：
10.1152/jn.00714.2014
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发表时间：
2015
影响因子：
2.5
通讯作者：
J. Hofmeijer
中科院分区：
文献类型：
--
作者：
M. V. van Putten;M. Tjepkema;J. Hofmeijer
Infraslow 活动代表生理和病理脑功能的重要组成部分。我们使用连续全带头皮脑电图，研究了 41 名心脏骤停后缺氧昏迷患者的下慢活动（<0.1 Hz），包括下慢活动与 3-30 Hz 范围内的脑电图功率之间的关系。在所有患者中，无论常规频带中的神经系统结果或脑电图活动如何，都存在下慢活动（0.015-0.06 Hz）。两名患者存在低幅度 (10-30 μV) 的低速活动，而 EEG 显示没有高于 0.5 Hz 的节律活动。在 13/15 的预后良好的患者和 20/26 的预后较差的患者中，3-30 Hz 频率范围内的 EEG 功率与下慢活动阶段相关，通过调制指数进行量化。在具有相同爆发的爆发抑制的 9/14 患者中，爆发成簇出现，与次慢振荡锁相。这通过最小计算模型中的突发抑制模拟得到证实。缺氧后脑病中保留了 Infraslow 活性并调节皮质兴奋性。在患有严重缺氧后脑病和具有相同爆发的爆发抑制的患者中观察到最强的调节。
Infraslow activity represents an important component of physiological and pathological brain function. We study infraslow activity (<0.1 Hz) in 41 patients with postanoxic coma after cardiac arrest, including the relationship between infraslow activity and EEG power in the 3-30 Hz range, using continuous full-band scalp EEG. In all patients, infraslow activity (0.015-0.06 Hz) was present, irrespective of neurological outcome or EEG activity in the conventional frequency bands. In two patients, low-amplitude (10-30 μV) infraslow activity was present while the EEG showed no rhythmic activity above 0.5 Hz. In 13/15 patients with a good outcome and 20/26 patients with a poor one, EEG power in the 3-30 Hz frequency range was correlated with the phase of infraslow activity, quantified by the modulation index. In 9/14 patients with burst-suppression with identical bursts, bursts appeared in clusters, phase-locked to the infraslow oscillations. This is substantiated by a simulation of burst-suppression in a minimal computational model. Infraslow activity is preserved in postanoxic encephalopathy and modulates cortical excitability. The strongest modulation is observed in patients with severe postanoxic encephalopathy and burst-suppression with identical bursts.
影响因子：
2.5
作者：
Tort, Adriano B. L.;Komorowski, Robert;Kopell, Nancy
通讯作者：
Kopell, Nancy
影响因子：
2.7
作者：
Zelmann, R.;Lina, J. M.;Jacobs, J.
通讯作者：
Jacobs, J.