Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells.
Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells.
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DOI：
10.1161/atvbaha.114.303219
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Jin SW
中科院分区：
文献类型：
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作者：
Kim JD;Lee HW;Jin SW
内皮细胞是一组高度多样化的细胞，对外源性刺激表现出不同的细胞反应。虽然恰当命名的血管内皮生长因子-A（VEGF-A）信号传导途径被誉为内皮细胞的最重要的信号传导输入，但其他因子也参与调节内皮行为和功能的各个方面。鉴于这种异质性，这些额外的因素似乎在创造定制环境以调节不同内皮细胞亚群的行为和功能方面发挥关键作用。例如，调节动脉血管床形态发生的分子线索可以与控制静脉血管床形态发生的分子线索完全不同。最近，我们发现，骨形态发生蛋白（BMP）信号选择性地促进血管生成从静脉血管床没有引起类似的反应，从动脉血管床在斑马鱼，表明BMP信号作为一个上下文依赖性调节器在血管形态发生的功能。在这篇综述中，我们将提供一个概述的分子机制，支持促血管生成的BMP信号对静脉血管床的背景下，内皮异质性的影响，并提出一个更全面的图片血管形态发生的分子机制在发展过程中。
Endothelial cells are a highly diverse group of cells which display distinct cellular responses to exogenous stimuli. While the aptly named Vascular Endothelial Growth Factor -A(VEGF-A) signaling pathway is hailed as the most important signaling input for endothelial cells, additional factors also participate in regulating diverse aspects of endothelial behaviors and functions. Given this heterogeneity, these additional factors appear to play a critical role in creating a custom-tailored environment to regulate behaviors and functions of distinct subgroups of endothelial cells. For instance, molecular cues that modulate morphogenesis of arterial vascular beds can be quite distinct from those that govern morphogenesis of venous vascular beds. Recently, we have found that Bone Morphogenetic Protein (BMP) signaling selectively promotes angiogenesis from venous vascular beds without eliciting similar responses from arterial vascular beds in zebrafish, indicating that BMP signaling functions as a context-dependent regulator during vascular morphogenesis. In this review, we will provide an overview of the molecular mechanisms that underlie pro-angiogenic effects of BMP signaling on venous vascular beds in the context of endothelial heterogeneity, and suggest a more comprehensive picture of the molecular mechanisms of vascular morphogenesis during development.