Mangiferin mitigates diabetic cardiomyopathy in streptozotocin-diabetic rats
Mangiferin mitigates diabetic cardiomyopathy in streptozotocin-diabetic rats
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DOI：
10.1139/cjpp-2013-0090
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发表时间：
2013-09-01
影响因子：
2.1
通讯作者：
Hu, Yonghe
中科院分区：
文献类型：
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作者：
Hou, Jun;Zheng, Dezhi;Hu, Yonghe
本研究的目的是探讨芒果苷对糖尿病心肌病（DCM）的心脏保护作用。 DCM模型是通过高脂肪饮食和低剂量链脲佐菌素诱导的。我们通过连续超声心动图、电子显微镜、心肌细胞纤维化区域的组织病理学分析以及基质金属蛋白酶-2 (MMP-2) 和 MMP-9 表达的蛋白质印迹分析来评估 DCM 的特征。 DCM 大鼠表现出严重的左心室功能障碍和心脏纤维化。芒果苷可减轻 DCM 并防止心肌胶原蛋白的积累。这些解剖学发现伴随着心脏功能的显着改善。基于这些结果，我们得出结论，芒果苷对扩张型心肌病具有治疗作用，并能改善心脏功能。
The purpose of this study was to investigate the cardioprotective effect of mangiferin on diabetic cardiomyopathy (DCM). The DCM model was induced by a high-fat diet and a low dose of streptozotocin. We evaluated the characteristics of DCM by serial echocardiography, electron microscopy, histopathologic analysis of cardiomyocyte fibrosis area, and Western blot analysis of matrix metalloproteinase-2 (MMP-2) and MMP-9 expression. Rats with DCM showed severe left ventricular dysfunction and cardiac fibrosis. Mangiferin mitigated DCM and prevented the accumulation of myocardial collagen. These anatomic findings were accompanied by significant improvements in cardiac function. Based on these results, we conclude that mangiferin has a therapeutic effect on DCM and improves cardiac function.