Myelin, copper, and the cuprizone model of schizophrenia.
Myelin, copper, and the cuprizone model of schizophrenia.
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DOI：
10.2741/s129
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Konradi C
中科院分区：
文献类型：
--
作者：
Herring NR;Konradi C
近年来，越来越多的证据指向精神分裂症和其他精神疾病的白色物质异常。本文就髓磷脂在认知和脑功能中的作用及其与脑功能障碍的关系作一综述。此外，我们将检查一个特定的实验模型，用于研究髓鞘形成障碍，由毒素cuprizone的管理。铜的螯合剂，铜的螯合剂，导致白色物质异常的啮齿动物。在特定的发育时期给予cuprizone允许靶向特定的脑区域用于髓鞘形成障碍。因此，cuprizone可用于研究中枢神经系统中髓鞘缺乏的发病机制和病理生理学，以及其对精神疾病相关行为的影响。
In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders. The present paper will provide an overview over the role of myelin in cognition and brain function, and its potential involvement in brain disorders. Furthermore, we will examine one particular experimental model for the study of dysmyelination, created by the administration of the toxin cuprizone. Cuprizone, a copper chelator, causes white matter abnormalities in rodents. The administration of cuprizone during specific developmental periods allows for the targeting of specific brain areas for dysmyelination. Thus, cuprizone can be used to study the pathogenesis and pathophysiology of myelin deficiencies in the central nervous system, and its effect on behaviors relevant to psychiatric disorders.