A randomized double-blind clinical trial of the effect of chondroitin sulfate and glucosamine hydrochloride on temporomandibular joint disorders: A pilot study
A randomized double-blind clinical trial of the effect of chondroitin sulfate and glucosamine hydrochloride on temporomandibular joint disorders: A pilot study
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DOI：
10.1080/08869634.2001.11746162
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发表时间：
2001-04-01
影响因子：
1.6
通讯作者：
Salinas, T
中科院分区：
文献类型：
--
作者：
Nguyen, P;Mohamed, SE;Salinas, T
以前的研究表明硫酸软骨素和盐酸氨基葡萄糖对膝关节骨关节炎的症状有有益的影响。我们的目的是研究每日1500 mg盐酸氨基葡萄糖（GH）和1200 mg硫酸软骨素（CS）对诊断为关节囊炎、椎间盘移位、椎间盘脱位或颞下颌关节（TMJ）疼痛性骨关节炎的受试者的影响，持续12周。45例受试者入组研究，并随机分配至活性药物组或安慰剂组。11例受试者因各种原因从研究中脱落，导致14例受试者留在活性药物组，20例受试者留在安慰剂组。通过麦吉尔疼痛问卷的一个指数测量，服用CS-GH的受试者的疼痛、TMJ压痛、TMJ声音和每日所需的非处方药数量均有改善。通过视觉模拟量表和麦吉尔疼痛问卷的四个指数测量，服用安慰剂药物的受试者的疼痛有所改善。需要进一步的研究来评估CS-GH的临床有效性，并确定CS-GH影响滑膜关节软骨的确切机制。
Previous studies have shown chondroitin sulfate and glucosamine hydrochloride have beneficial effects on symptoms of osteoarthritis of the knee. Our aim was to study the effect of a daily dose of 1500 mg of glucosamine hydrochloride (GH) and 1200 mg of chondroitin sulfate (CS) taken for twelve weeks on subjects diagnosed with capsulitis, disk displacement, disk dislocation, or painful osteoarthritis of the temporomandibular joint (TMJ). Forty-five subjects were enrolled in the study and were randomly assigned to either an active medication group or a placebo group. Eleven subjects were lost from the study for Various reasons, resulting in fourteen subjects remaining in the active medication group and twenty subjects remaining in the placebo group. Subjects taking CS-GH had improvements in their pain as measured by one index of the McGill Pain Questionnaire, in TMJ tenderness, in TMJ sounds, and in the number of daily over-the-counter medications needed. Subjects taking the placebo medication had improvements in their pains as measured by the visual analog scale and by four indices of the McGill Pain Questionnaire. Additional studies are required to evaluate the clinical effectiveness of CS-GH and to determine the exact mechanism by which CS-GH affects the articular cartilage of synovial joints.