Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
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DOI：
10.3390/genes10050378
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发表时间：
2019-05-01
期刊：
影响因子：
3.5
通讯作者：
Corominas, Montserrat
中科院分区：
文献类型：
--
作者：
Camilleri-Robles, Carlos;Serras, Florenci;Corominas, Montserrat
GADD 45蛋白在应激反应中被诱导，并参与多种细胞功能的调节，包括DNA修复、细胞周期控制、衰老和凋亡。在这项研究中，我们研究了D-GADD 45在果蝇发育和翅盘再生过程中的作用。我们发现D-GADD 45的高表达导致JNK依赖性凋亡，而其暂时表达没有有害影响。此外，D-GADD 45是翅盘正常再生所必需的。我们的研究结果表明，D-GADD 45水平的严格调节是其正确功能所必需的，无论是在发育过程中还是在细胞死亡后的应激反应中。
The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death.