Functional Crosstalk Between Cell-Surface and Intracellular Channels Mediated by Junctophilins Essential for Neuronal Functions
Functional Crosstalk Between Cell-Surface and Intracellular Channels Mediated by Junctophilins Essential for Neuronal Functions
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DOI：
10.1007/s12311-008-0040-1
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发表时间：
2008-09-01
期刊：
影响因子：
3.5
通讯作者：
Takeshima, Hiroshi
中科院分区：
文献类型：
--
作者：
Kakizawa, Sho;Moriguchi, Shigeki;Takeshima, Hiroshi
连接亲蛋白（Junctophilins, JPs）参与质膜和内质/肌浆网之间连接膜复合物的形成，并为肌细胞兴奋-收缩耦合过程中的通道通信提供结构平台。在大脑中，两种神经元JP亚型在神经元中广泛表达。最近的研究已经明确了神经jp在细胞表面和细胞内通道之间的交流中所起的重要作用，它调节了小脑和海马神经元的兴奋性和突触可塑性。
Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.