Cardiac Regeneration
Cardiac Regeneration
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DOI：
10.1007/978-3-319-56106-6
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Markus Hecker;Masaki Ieda;Wolfram-Hubertus Zimmermann
中科院分区：
文献类型：
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作者：
Markus Hecker;Masaki Ieda;Wolfram-Hubertus Zimmermann
在过去的十年中，心脏再生领域在开发新疗法方面取得了重大进展。成人心脏再生的策略在实验和临床领域都在不断发展。尽管干细胞疗法仍然存在争议，但基于细胞的心脏修复是一种有前途的成人心脏再生方法。细胞治疗的经验在临床研究中取得了几个重要的里程碑。在细胞疗法为广大患者实现再生潜力之前，仍然存在重要的障碍。在本章中，我们重点关注心脏细胞修复和治疗策略的历史，并讨论基于细胞的心脏再生的经验教训。
The field of heart regeneration has witnessed significant advancements toward developing new therapeutics in the past decade. Strategies to regenerate the adult human heart are in constant development in both the experimental and clinical arenas. Although stem cell therapies remain controversial, cell-based heart repair is a promising approach toward regenerating the adult human heart. Experience with cell therapy has resulted in several important milestones in clinical studies. There are still important roadblocks ahead before cell therapy can achieve the regeneration potential for broad numbers of patients. In this chapter, we focus on the history of cardiac cell repair and therapeutic strategies and discuss the lessons learned in cell-based heart regeneration.