Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma
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DOI：
10.3233/dma-2011-0812
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Jiang, Song
中科院分区：
文献类型：
--
作者：
Liu, Dong-Cai;Yang, Zhu-Lin;Jiang, Song
本研究应用免疫组织化学方法检测了Msi-1和ALDH 1在胆囊腺癌（n = 100）、癌旁组织（n = 46）、腺瘤性息肉（n = 15）和慢性胆囊炎（n = 35）中的表达。Msi-1和ALDH 1在胆囊腺癌中的阳性表达率明显高于癌旁组织、腺瘤性息肉和慢性胆囊炎（p < 0.01）。Msi-1和ALDH 1的表达与腺癌的分化程度、肿块大小、淋巴结转移和浸润深度密切相关。Msi-1和ALDH-1在胆囊腺癌中的表达高度一致（p < 0.01）。单变量Kaplan-Meier分析显示Msi-1（p = 0.042）或ALDH 1（p < 0.001）表达与总生存率呈负相关。Msi-1和ALDH 1均低表达或无表达的患者的平均生存时间显著长于其他三种亚型的患者（p < 0.001）。多因素考克斯回归分析显示，Msi-1和ALDH 1的阳性表达（分别为p = 0.016和p = 0.006）是胆囊腺癌预后不良的独立预测因子。本研究提示Msi-1和/或ALDH 1的表达可能与胆囊腺癌的发生、发展、临床生物学行为及预后密切相关。
In this study, we investigated the expressions of Msi-1 and ALDH1 in gallbladder adenocarcinoma (n = 100), peritumoral tissues (n = 46), adenomatous polyp (n = 15), and chronic cholecystitis (n = 35) using immunohistochemical method. The percentage of cases with positive Msi-1 and ALDH1 expression were significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues, adenomatous polyp and chronic cholecystitis (ps < 0.01). The expression of Msi-1 and ALDH1 was significantly associated with differentiation, tumor mass, lymph node metastasis and invasion of adenocarcinoma. The expression of Msi-1 and ALDH1 was found to be highly consistent in gallbladder adenocarcinoma (p < 0.01). Univariate Kaplan-Meier analysis showed a negative correlation between Msi-1 (p = 0.042) or ALDH1 (p < 0.001) expression with overall survival. The average survival time of patients with both low or no Msi-1 expression and ALDH1 expression was significantly longer than patients with the other three subtypes (p < 0.001). Multivariate Cox regression analysis showed that positive expression of Msi-1 or ALDH1 (p = 0.016, p = 0.006, respectively) was an independent bad-prognostic predictor in gallbladder adenocarcinoma. Our study suggested that Msi-1 and/or ALDH1 expression might be closely related to the carcinogenesis, progression, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.