Problems with Using Polygenic Scores to Select Embryos.
Problems with Using Polygenic Scores to Select Embryos.
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DOI：
10.1056/nejmsr2105065
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发表时间：
2021-07-01
期刊：
影响因子：
--
通讯作者：
Visscher PM
中科院分区：
文献类型：
--
作者：
Turley P;Meyer MN;Wang N;Cesarini D;Hammonds E;Martin AR;Neale BM;Rehm HL;Wilkins-Haug L;Benjamin DJ;Hyman S;Laibson D;Visscher PM
公司最近开始向考虑体外受精的患者出售一项新服务：基于多基因评分的胚胎选择（ESPS）。这些分数代表了对健康和其他结果的个性化预测，这些结果来自成人全基因组关联研究，以部分预测这些结果。本文讨论了在胚胎选择的背景下降低多基因评分预测能力的许多因素，并量化了这些因素对各种临床和非临床性状的影响。还讨论了ESPS的潜在意外后果（包括选择不利特征，改变人口统计学，加剧社会不平等，以及贬低某些特征）。提供了从业者对ESPS负责任的沟通建议，并呼吁全社会对这项技术进行对话。（由国家老龄化研究所和其他机构资助。
Companies have recently begun to sell a new service to patients considering in vitro fertilization: embryo selection based on polygenic scores (ESPS). These scores represent individualized predictions of health and other outcomes derived from genomewide association studies in adults to partially predict these outcomes. This article includes a discussion of many factors that lower the predictive power of polygenic scores in the context of embryo selection and quantifies these effects for a variety of clinical and nonclinical traits. Also discussed are potential unintended consequences of ESPS (including selecting for adverse traits, altering population demographics, exacerbating inequalities in society, and devaluing certain traits). Recommendations for the responsible communication about ESPS by practitioners are provided, and a call for a society-wide conversation about this technology is made. (Funded by the National Institute on Aging and others.)
影响因子：
3.9
作者：
Pergament D;Ilijic K
通讯作者：
Ilijic K