HIV-1 capsid: the multifaceted key player in HIV-1 infection.
HIV-1 capsid: the multifaceted key player in HIV-1 infection.
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DOI：
10.1038/nrmicro3503
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Hope TJ
中科院分区：
文献类型：
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作者：
Campbell EM;Hope TJ
在成熟的、具有感染性的HIV-1病毒粒子中，病毒基因组位于由病毒衣壳(CA)蛋白组成的圆锥形衣壳核心内。CA蛋白及其组装成的结构通过与多种宿主细胞因子的一系列相互作用，促进了感染的几乎每一步。这篇综述描述了我们对病毒衣壳核心与几种细胞因子之间的相互作用的理解，这些因子使得HIV-1基因组能够有效地复制、及时的核心分解、核导入以及病毒基因组整合到靶细胞的基因组中。然后我们讨论如何阐明这些相互作用可以揭示针对HIV-1的治疗相互作用的新靶点。
In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core comprised of the viral capsid (CA) protein. The CA protein, and the structure into which it assembles, facilitate virtually every step of infection through a series of interactions with multiple host cell factors. This review describes our understanding of the interactions between the viral capsid core and several cellular factors that enable efficient HIV-1 genome replication, timely core disassembly, nuclear import and the integration of the viral genome into the genome of the target cell. We then discuss how elucidating these interactions can reveal new targets for therapeutic interactions against HIV-1.