UV-B exposure impairs resistance to infection by Trichinella spiralis.
UV-B exposure impairs resistance to infection by Trichinella spiralis.
复制标题
UV-B暴露会损害螺旋状螺旋菌对感染的抵抗。
DOI：
10.1289/ehp.94102298
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发表时间：
1994-03
影响因子：
10.4
通讯作者：
van Loveren, H
中科院分区：
文献类型：
--
作者：
Goettsch, W;Garssen, J;Deijns, A;de Gruijl, F R;van Loveren, H
为了评估地球表面UV-B暴露增加可能导致对几种传染病的抵抗力受损的可能性，我们研究了UV-B暴露对旋毛虫抵抗力的影响。Wistar大鼠经口感染T.在感染前或感染后的不同时间段，每天暴露于皮下剂量的UV-B辐射5天。在感染后6至10天之间，用UV-B照射的大鼠尸体中发现旋毛虫幼虫数量显著增加。这些数据表明，暴露于UV-B辐射抑制抵抗寄生虫感染。我们认为，UV-B辐射，特别是抑制对这些蠕虫的细胞免疫反应，因为特定的IgM，IgG和IgE滴度并没有显着改变UV-B暴露。这些数据表明，UV-B辐射在T.这表明UV-B暴露的增加也可能导致其他传染病的问题，并可能影响疫苗接种，因为UV-B辐射与记忆T细胞的相互作用。
To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses of UV-B radiation daily for 5 days at different time periods before or after infection. A significant increase in the number of Trichinella larvae was found in the carcasses of rats irradiated with UV-B between 6 and 10 days after infection. These data indicate that exposure to UV-B radiation suppresses the resistance to a parasitic infection. We suggested that UV-B radiation especially suppresses cellular immune responses against these worms because specific IgM, IgG, and IgE titers were not significantly altered by UV-B exposure. These data indicate that UV-B irradiation plays a role in the course of infection with T. spiralis, which suggests that increases of UV-B exposure might also lead to problems with other infectious diseases and might affect vaccination because of the interaction of UV-B irradiation with memory T-cells.