Therapeutic interventions for alcohol dependence in non-inpatient settings: a systematic review and network meta-analysis (protocol).
Therapeutic interventions for alcohol dependence in non-inpatient settings: a systematic review and network meta-analysis (protocol).
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DOI：
10.1186/s13643-017-0462-2
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发表时间：
2017-04-11
影响因子：
3.7
通讯作者：
Kessler D
中科院分区：
文献类型：
--
作者：
Cheng HY;Elbers RG;Higgins JP;Taylor A;MacArthur GJ;McGuinness L;Dawson S;López-López JA;Cowlishaw S;Hickman M;Kessler D
酒精依赖是社会和身体伤害的常见和严重原因。然而，对中度和重度酒精依赖者戒毒后在初级和社区护理中的最佳管理仍不清楚。本综述的目的是评估干预措施的有效性，以保持戒酒的人与酒精依赖脱毒后。我们将系统地检索电子数据库和临床试验登记处的随机对照试验（RCTs），以检查药理学和/或心理社会干预对最近脱毒的酒精依赖成年人保持禁欲的有效性。检索将通过检查纳入研究和其他相关系统综述的参考文献和引文进行补充。没有语言、年份或出版状态的限制。将使用预先规定的标准选择RCT。将提取符合条件的RCT的描述性信息、研究特征和结果。将使用修订版的科克伦偏倚风险工具（RoB 2.0）评估合格RCT中的偏倚风险。将使用网络荟萃分析（NMA）对结果进行综合和分析。将评价证据的总体强度和发表偏倚。还将进行亚组和敏感性分析。该网络荟萃分析旨在评估和总结需要戒毒支持并可在社区接受治疗的酒精依赖患者的治疗干预措施的全部证据。这些证据将决定哪种干预措施的组合对目前的实践和进一步的调查最有希望。PROSPERO CRD 42016049779本文的在线版本（doi：10.1186/s13643-017-0462-2）包含补充材料，可供授权用户使用。
Alcohol dependence is common and serious cause of social and physical harm. However, the optimal management of those with moderate and severe alcohol dependence in primary and community care after detoxification remains unclear. The aim of this review is to evaluate the effectiveness of interventions for maintaining abstinence in people with alcohol dependence following detoxification. We will systematically search electronic databases and clinical trial registries for randomized controlled trials (RCTs) examining the effectiveness of pharmacological and/or psychosocial interventions for maintaining abstinence in recently detoxified, alcohol-dependent adults. The searches will be complemented by checking references and citations from included studies and other relevant systematic reviews. No limitation on language, year, or publication status will be applied. RCTs will be selected using prespecified criteria. Descriptive information, study characteristics, and results of eligible RCTs will be extracted. A revised version of the Cochrane Risk of Bias tool (RoB 2.0) will be used to assess the risk of bias in eligible RCTs. Results will be synthesized and analyzed using network meta-analysis (NMA). Overall strength of the evidence and publication bias will be evaluated. Subgroup and sensitivity analysis will also be performed. This network meta-analysis aims to appraise and summarize the total evidence of therapeutic interventions for alcohol-dependent patients that require support for detoxification and can be treated in the community. The evidence will determine which combination of interventions are most promising for current practice and further investigation. PROSPERO CRD42016049779 The online version of this article (doi:10.1186/s13643-017-0462-2) contains supplementary material, which is available to authorized users.