Some species differences in the false prolongation of prothrombin times and activated partial thromboplastin times in toxicology
Some species differences in the false prolongation of prothrombin times and activated partial thromboplastin times in toxicology
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毒理学中凝血酶原时间和活化部分凝血活酶时间假性延长的一些物种差异
DOI：
10.1007/bf00638933
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
T. Matsuzawa
中科院分区：
文献类型：
--
作者：
H. Tabata;S. Nakamura;T. Matsuzawa
在 4°C 和 25°C 的储存温度下长达 96 小时，检查小鼠、大鼠、兔、狗、猴子和人类血浆活化部分凝血活酶时间 (APTT) 和凝血酶原时间 (PT) 的变化。大鼠的 APTT 延长迅速且显着，采样后 24 小时内延长了一倍。人和猴的血浆 APTT 也受到影响，但程度较轻。在小鼠、兔子和狗中没有观察到效果。另一方面，所有物种中 PT 变化的幅度远小于 APTT 观察到的变化。对于任一测试，在 4°C 或 25°C 下储存的样品的结果均未发现显着差异。APTT 的错误延长在毒性研究中显然是不受欢迎的，尤其是在大鼠中。因此，通过在严格的时间控制条件下执行此测试来最大限度地减少这些变化非常重要。
Changes in plasma activated partial thromboplastin times (APTT) and prothrombin times (PT) in mice, rats, rabbits, dogs, monkeys and human were examined for up to 96 h at storage temperatures of 4 and 25°C. Prolongation of APTT in rats was rapid and marked, with times doubling within 24 h post-sampling. Plasma APTT of human and monkey were also affected, but to a lesser extent. No effect was observed in mice, rabbits and dogs. On the other hand, the magnitude of PT changes was much smaller than that observed with APTT in all species. No significant differences were noted between the results from samples stored at 4°C or 25°C for either test.The false prolongation of APTT is clearly undesirable in a toxicity study, especially in rats. It is important therefore to minimise these changes by performing this test under strict time-controlled conditions.