Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
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DOI：
10.1128/aac.02189-13
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发表时间：
2014-04-01
影响因子：
4.9
通讯作者：
Colombo, Arnaldo L.
中科院分区：
文献类型：
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作者：
Bizerra, Fernando Cesar;Jimenez-Ortigosa, Cristina;Colombo, Arnaldo L.
我们发现一例25岁患者在接受米卡芬净预防治疗（50 mg/天）后发生突破性念珠菌血症。从血培养中获得了5株光滑念珠菌分离株，并将其归类为多重耐药分离株，因为它们对棘白菌素和唑类药物均表现出较高的MIC。FKS 2基因的热点1突变（S663 F）在所有5个分离株中发现。这种突变产生了1，3-β-D-葡聚糖合成酶，对棘白菌素药物的敏感性大大降低。
We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azole drugs. A mutation (S663F) in hot spot 1 of the FKS2 gene was found in all five isolates. This mutation yielded a 1,3-beta-D-glucan synthase enzyme with highly reduced sensitivities to echinocandin drugs.