The soma-germline communication: implications for somatic and reproductive aging.
The soma-germline communication: implications for somatic and reproductive aging.
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DOI：
10.5483/bmbrep.2021.54.5.198
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发表时间：
2021-05
期刊：
影响因子：
3.8
通讯作者：
Lee MH
中科院分区：
文献类型：
--
作者：
Gaddy MA;Kuang S;Alfhili MA;Lee MH
衰老的特征是大多数生理过程的功能下降，包括细胞代谢和防御机制的改变。越来越多的证据表明，热量限制延长寿命和延缓与年龄有关的疾病，至少部分是通过降低各种物种的代谢率和氧化应激，包括酵母，蠕虫，苍蝇和小鼠。此外，最近对无脊椎动物-蠕虫和苍蝇-的研究突出了生殖寿命和躯体衰老之间错综复杂的相互关系（称为衰老的可抛弃索马理论），这一理论似乎在脊椎动物中得到了保留。这篇综述特别关注生殖系统如何调节体细胞衰老，反之亦然，在遗传模型系统。由于许多控制衰老过程的信号通路在进化上是保守的，因此在脊椎动物中可能涉及类似的机制来控制索马和生殖衰老。
Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate and oxidative stress in a variety of species, including yeast, worms, flies, and mice. Moreover, recent studies in invertebrates – worms and flies, highlight the intricate interrelation between reproductive longevity and somatic aging (known as disposable soma theory of aging), which appears to be conserved in vertebrates. This review is specifically focused on how the reproductive system modulates somatic aging and vice versa in genetic model systems. Since many signaling pathways governing the aging process are evolutionarily conserved, similar mechanisms may be involved in controlling soma and reproductive aging in vertebrates.