Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast
Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast
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DOI：
10.1136/jclinpath-2012-201405
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发表时间：
2013-08-01
影响因子：
3.4
通讯作者：
Paik, Seung Sam
中科院分区：
文献类型：
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作者：
Jang, Se Min;Sim, Jongmin;Paik, Seung Sam
细胞粘附分子4（CADM 4）是一种新的肿瘤抑制因子，参与细胞粘附。CADM4表达的缺失或降低与某些癌症的发生和进展有关。为探讨CADM 4在乳腺癌组织中的表达及其临床病理意义，采用免疫组织化学方法检测了256例乳腺浸润性导管癌（IDC）和45例乳腺导管原位癌（DCIS）组织中CADM 4的表达，并与乳腺癌的临床病理特征进行比较。DCIS组82.2%，IDC组173例，占67.6%。CADM4在DCIS中的表达高于IDC（p=0.049）。CADM4表达的缺失或减少与较高的组织学分级（p=0.020）、雌激素受体缺乏（p
Aims Cell adhesion molecule 4 (CADM4) is a novel tumour suppressor involved in cell adhesion. Loss or decreased expression of CADM4 has been associated with the development and progression of some cancers. The purpose of this study was to investigate the clinicopathological significance of CADM4 expression in breast cancer.Methods We constructed tissue microarrays to evaluate the immunohistochemical expression of CADM4 in 256 cases of invasive ductal carcinoma (IDC) and 45 cases of ductal carcinoma in situ (DCIS).Results CADM4 was expressed in 37 (82.2%) DCIS cases, and in 173 (67.6%) IDC cases. CADM4 expression was higher in DCIS than in IDC (p=0.049). Loss or decrease of CADM4 expression was significantly correlated with higher histological grade (p=0.020), absence of oestrogen receptors (p