Transcription factors that influence RNA polymerases I and II: To what extent is mechanism of action conserved?
Transcription factors that influence RNA polymerases I and II: To what extent is mechanism of action conserved?
复制标题
影响RNA聚合酶I和II的转录因子：作用机理在多大程度上保守了？
DOI：
10.1016/j.bbagrm.2016.10.010
复制
发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Schneider DA
中科院分区：
文献类型：
--
作者：
Zhang Y;Najmi SM;Schneider DA
在真核细胞中，核RNA合成由至少三种独特的多亚基RNA聚合酶完成。这些酶的作用通常分为三大类RNA的合成：RNA聚合酶I、II和III的rRNA、mRNA和tRNA。与其独特的细胞作用一致，每种酶都有一系列专门的转录因子和酶特性。然而，并不是所有的转录因子都进化成只影响一种真核RNA聚合酶。事实上，许多因素已被证明会影响多种核RNA聚合酶的活性。这篇评论集中在这些因素的一个子集，特别是解决这些蛋白质的影响RNA聚合酶I和II的机制。
In eukaryotic cells, nuclear RNA synthesis is accomplished by at least three unique, multisubunit RNA polymerases. The roles of these enzymes are generally partitioned into the synthesis of the three major classes of RNA: rRNA, mRNA, and tRNA for RNA polymerases I, II, and III respectively. Consistent with their unique cellular roles, each enzyme has a complement of specialized transcription factors and enzymatic properties. However, not all transcription factors have evolved to affect only one eukaryotic RNA polymerase. In fact, many factors have been shown to influence the activities of multiple nuclear RNA polymerases. This review focuses on a subset of these factors, specifically addressing the mechanisms by which these proteins influence RNA polymerases I and II.