An immune regulatory cytokine receptor and glioblastoma multiforme: an unexpected link.
An immune regulatory cytokine receptor and glioblastoma multiforme: an unexpected link.
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免疫调节细胞因子受体和多形性胶质母细胞瘤：意想不到的联系。
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发表时间：
1998
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通讯作者：
Waldemar Debinski
中科院分区：
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作者：
Waldemar Debinski
人类高级胶质瘤（HGG）是最具破坏性的人类恶性肿瘤之一。它们是迅速发展的异质肿瘤，目前尚无治愈的治疗方法。虽然这些肿瘤被认为是神经胶质细胞起源，但已知的肿瘤特异性标记物并不能表征它们。导致或促进HGG发展的具体环境条件尚不清楚。HGG的发病机制尚不清楚，但更具体的遗传改变被认为与HGG有关。最近，我们发现HGG过度表达一种免疫调节细胞因子白细胞介素-13 （IL-13）的受体。事实上，似乎所有多形性胶质母细胞瘤患者都可能具有这种受体。IL-13是一种抗炎细胞因子，与它的同源物IL-4有许多重叠的功能。在HGG中IL-13受体的过表达具有高度的特异性。该受体不仅在数量上，而且在质量上都不同于正常组织中唯一已知的IL-13功能信号受体。它不与IL-4共享。因此，限制性更强的IL-13受体可能代表了一种新的因子，专门针对像HGG这样的异质疾病。
Human high-grade gliomas (HGG) are one of the most devastating human malignancies. They are rapidly progressing heterogenous tumors for which no curable treatment is available. Although these tumors are believed to be of glial cell origin, known tumor-specific markers do not characterize them. The specific environmental conditions that cause or promote the development of HGG are not known. The pathomechanism of HGG is yet to be revealed, although more specific genetic alterations are assigned to HGG. Recently, we have found that HGG overexpress a receptor for an immune regulatory cytokine, interleukin-13 (IL-13). In fact, it appears that all patients with glioblastoma multiforme may possess this receptor. IL-13 is an antiinflammatory cytokine with many overlapping functions to its homologue, IL-4. There is a high degree of specificity of the overexpression of the IL-13 receptor in HGG. This receptor is not only quantitatively but also qualitatively different from the only known functional signaling receptor for IL-13 of normal tissue. It is not shared with IL-4. The more restrictive receptor for IL-13 thus may represent a new factor specific for a disease as heterogenous as HGG.