Angiotensin type 2 receptor is important in the normal development of the ureter.
Angiotensin type 2 receptor is important in the normal development of the ureter.
复制标题
2 型血管紧张素受体对于输尿管的正常发育非常重要。
DOI：
10.1007/s004670050589
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Kon,V
中科院分区：
文献类型：
--
作者：
Hohenfellner,K;Hunley,TE;Schloemer,C;Brenner,W;Yerkes,E;Zepp,F;Brock3rd,JW;Kon,V
在人类中，血管紧张素 II 的作用是通过 AT1 和 AT2 受体转导的，最近这些受体与肾器官发生有关。人类血管紧张素 II 受体基因的多态性与心血管和肾脏疾病有关。在这项研究中，我们评估了 35 名患有原发性梗阻巨输尿管或后尿道瓣膜的患者。每个都针对 A1166AT1 多态性和最近描述的 A-1332GAT2 转变进行了基因分型。还在没有任何超声检查泌尿系统异常的正常对照中评估了这些遗传变异的发生率。与我们之前在先天性泌尿系统异常中的发现类似，原发性梗阻性巨输尿管或后尿道瓣膜患者与对照患者之间的 AT1 受体基因型分布没有差异。相反，与正常对照相比，原发性梗阻性巨输尿管患者AT2A-1332G转变的发生率显着增加（75.0% vs. 41.9%，P<0.025）。在有后尿道瓣膜的患者中，与对照组相比，过渡的发生率没有差异（36.9%，P=NS）。因此，AT1受体基因多态性与泌尿系统异常之间不存在相关性。然而，原发性梗阻性巨输尿管患者中 AT2 基因变异的发生率有所增加。
In humans, the actions of angiotensin II are transduced through the AT1 and AT2 receptors which have recently been implicated in renal organogenesis. Polymorphisms in the human angiotensin II receptor genes have been linked to cardiovascular and nephrological disorders. In this study we evaluated 35 patients with either primary obstructive megaureter or posterior urethral valves. Each was genotyped for theA1166AT1 polymorphism and the recently describedA-1332GAT2 transition. The incidence of these genetic variants was also evaluated in normal controls without any ultrasonographic urological abnormalities. Similar to our previous findings in congenital urological abnormalities, the AT1 receptor genotype distribution did not differ between patients with either primary obstructive megaureter or posterior urethral valves versus controls. In contrast, compared with normal controls, there was a dramatic increase in the occurrence of the AT2A-1332Gtransition in patients with primary obstructive megaureter (75.0% vs. 41.9% in controls,P<0.025). In patients with posterior urethral valves, there was no difference in the occurrence of the transition versus controls (36.9%,P=NS). Thus, there is no correlation between the AT1 receptor gene polymorphism and urological abnormalities. However there is an increased incidence in the AT2 genetic variant in patients with primary obstructive megaureter.