Intracerebroventricular administration of brain-derived neurotrophic factor in adult rats affects analgesia and spontaneous behaviour but not memory retention in a Morris Water Maze task
Intracerebroventricular administration of brain-derived neurotrophic factor in adult rats affects analgesia and spontaneous behaviour but not memory retention in a Morris Water Maze task
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DOI：
10.1016/s0304-3940(00)01173-3
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发表时间：
2000-06-30
影响因子：
2.5
通讯作者：
Alleva, E
中科院分区：
文献类型：
--
作者：
Cirulli, F;Berry, A;Alleva, E
本研究测试了在莫里斯水迷宫（MWM）任务中体内施用脑源性神经营养因子（BDNF）及其抗体（抗BDNF）的效果。成年雄性大鼠在 MWM 中接受为期三天的训练。在最后一次训练试验结束时，受试者脑室内注射以下物质之一：（i）BDNF（24μg）； (ii)抗BDNF(25μg)；或(iii)媒介物(PBS，注射体积10μl)。第 5 天，测试受试者的记忆力、疼痛敏感性和运动行为。即使获得性试验数量减少，MWM 作为治疗功能也没有出现差异。尽管如此，BDNF 既影响热板测试中的疼痛阈值，也影响旷场测试中的探索行为。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
The present study tested the effects of in vivo administration of brain-derived neurotrophic factor (BDNF) and of its antibody (anti-BDNF) in a Morris Water Maze (MWM) task. Adult male rats were trained for three days in a MWM. At the end of the last training trial, subjects were injected intracerebroventricularly with one of the following: (i) BDNF (24 mu g); (ii) anti-BDNF (25 mu g); or (iii) vehicle (PBS, injection volume 10 mu l). On day 5, subjects were tested for memory retention, pain sensitivity and locomotor behaviour. No differences emerged in the MWM as a function of treatment, even with a reduced number of acquisition trials. Nonetheless, BDNF affected both pain threshold in the hot-plate test, as well as exploratory behaviour in the open field test. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.