Water influences the enantioselectivity in the proline or prolinamide-catalyzed aldol addition of acetone to isatins
Water influences the enantioselectivity in the proline or prolinamide-catalyzed aldol addition of acetone to isatins
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DOI：
10.1016/j.tetlet.2008.12.007
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发表时间：
2009-02-18
影响因子：
1.8
通讯作者：
Tomasini, Claudia
中科院分区：
文献类型：
--
作者：
Angelici, Gaetano;Correa, Rodrigo J.;Tomasini, Claudia
在脯氨酸或脯氨酰胺催化的丙酮与靛红的羟醛加成反应中加入少量的水可以提高对映选择性。DFT B3LYP计算与水分子明确纳入羟醛过渡态再现所观察到的对映选择性。(C)2008爱思唯尔有限公司保留所有权利。
The addition of small quantities of water to the proline or prolinamide-catalyzed aldol addition of acetone to isatin can result in increased enantioselectivity. DFT B3LYP calculations with a water molecule explicitly incorporated in the aldol transition states reproduce the observed enantioselectivity. (C) 2008 Elsevier Ltd. All rights reserved.