When should HAART be initiated in pregnancy to achieve an undetectable HIV viral load by delivery?
When should HAART be initiated in pregnancy to achieve an undetectable HIV viral load by delivery?
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DOI：
10.1097/qad.0b013e3283536a6c
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发表时间：
2012-06-01
期刊：
影响因子：
3.8
通讯作者：
de Ruiter, Annemiek
中科院分区：
文献类型：
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作者：
Read, Phillip J.;Mandalia, Sundhiya;de Ruiter, Annemiek
背景：高效抗逆转录病毒疗法可显著减少艾滋病毒母婴传播，如果病毒载量低，则允许阴道分娩。这项研究提供了数据的最佳时机短期HAART在pregnancy.Methods：回顾性多中心队列研究孕妇开始HAART在伦敦和布莱顿，英国。整理人口统计学、妊娠、药物类别、CD 4细胞计数和病毒载量结果。根据初始HIV病毒载量对达到低于50拷贝/ml的病毒载量的生存曲线进行分层。考克斯的比例风险回归模型进行了调整人口统计学和immunovirologicparameters.Results：病毒载量小于50拷贝/毫升，在292 378怀孕（77.2%）交付。治疗前病毒载量与所用时间相关，达到病毒载量低于50拷贝/ml的比例（P <0.05）。
Background: HAART dramatically reduces mother-to-child transmission of HIV allowing vaginal delivery if the viral load is low. This study provides data for the optimum timing of short-term HAART in pregnancy.Methods: Retrospective multicentre cohort study of pregnant women commencing HAART in London and Brighton, UK. Demographics, gestation, drug class, CD4 cell count, and viral load results were collated. Survival curves for reaching a viral load less than 50 copies/ml were stratified by initial HIV viral load. Cox's proportional hazards regression model was adjusted for demographics and immunovirological parameters.Results: Viral load was less than 50 copies/ml in 292 of 378 pregnancies (77.2%) by delivery. Pretreatment viral load was associated with the time taken, and the proportion achieving a viral load less than 50 copies/ml at (P