Deciphering components of impaired working memory in multiple sclerosis.
Deciphering components of impaired working memory in multiple sclerosis.
复制标题
破译多发性硬化症中工作记忆受损的组成部分。
DOI：
10.1097/00146965-200303000-00004
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
DeLuca,John
中科院分区：
文献类型：
--
作者：
Lengenfelder,Jean;Chiaravalloti,NancyD;Ricker,JosephH;DeLuca,John
目的通过检测多发性硬化（multiple sclerosis，MS）患者的听觉工作记忆（auditory working memory，WM）成分，以确定MS患者是否存在WM损害。（即，中央执行与存储/维护）方法对有或没有认知障碍的MS患者和健康对照者进行了一项主要评估储存量的任务，排练/维护（听觉n-回）和一个任务与一个显着的中央执行组件（节奏听觉串行加法任务）。然而，除了中央执行组件的处理似乎是区分与MS与认知障碍的个人从那些没有认知障碍和健康controls.ConclusionsResults表明，在MS的主要WM损害的关键因素是在中央执行，而不是语音环路。
ObjectiveTo identify working memory (WM) impairment by examining components of auditory working memory with the same sample of individuals with multiple sclerosis (MS).BackgroundAlthough individuals with MS have consistently demonstrated WM impairments, the specific components involved (ie, central executive versus storage/maintenance) remain unclear.MethodIndividuals with MS with and without cognitive impairment and healthy controls were administered a task primarily assessing storage and rehearsal/maintenance (auditory n-back) and a task with a significant central executive component (Paced Auditory Serial Addition Task).ResultsResults indicate when the phonological loop is minimally challenged, maintenance of information is generally efficient. However, the addition of a central executive component to processing appears to be the key factor in differentiating individuals with MS with cognitive impairment from those without cognitive impairment and healthy controls.ConclusionsResults indicated that the primary WM impairment in MS is within the central executive rather than the phonological loop.