Ambient formaldehyde and mortality: A time series analysis in China
Ambient formaldehyde and mortality: A time series analysis in China
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DOI：
10.1126/sciadv.abm4097
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发表时间：
2022-07-01
期刊：
影响因子：
13.6
通讯作者：
Li, Tiantian
中科院分区：
文献类型：
--
作者：
Ban, Jie;Su, Wenjing;Li, Tiantian
低水平甲醛对健康的潜在影响历来被忽视。我们进行了两阶段时间序列分析，以调查环境甲醛与每日非意外，循环和呼吸系统死亡率以及基于2013年至2018年中国275个县的5，325，585例死亡的6种亚型之间的关系，并估计了浓度-反应曲线以确定总体关联。在控制了来自气象因素、空气污染物、时间趋势和星期效应的混杂因素后，在lag 0天甲醛日浓度增加1 ppb，我们发现非意外、循环和呼吸系统疾病的死亡风险分别增加0.36%、0.36%和0.41%。该曲线表明，对非意外和循环系统疾病产生显著影响的可能阈值浓度约为5 ppb。我们认为，环境中的甲醛可能对公众健康构成潜在威胁，需要进一步调查，以支持及时的污染监管和健康保护。
The potential health impact of low-level ambient formaldehyde has been historically overlooked. We conducted a two-stage time series analysis to investigate associations between ambient formaldehyde and daily nonaccidental, circulatory, and respiratory mortality and six subtypes based on 5,325,585 deaths in 275 Chinese counties between 2013 and 2018 and estimated a concentration-response curve to identify overall associations. After controlling for confounders from meteorological factors, air pollutants, time trend, and day of the week effect, with a 1-part per billion (ppb) increase in the daily concentration of formaldehyde on lag0 day, we found that mortality risks in nonaccidental, circulatory, and respiratory diseases increased by 0.36%, 0.36% and 0.41%, respectively. The curve indicated a possible threshold concentration at approximately 5 ppb for significant impact on nonaccidental and circulatory diseases. We suggest that ambient formaldehyde may represent a potential threat to public health and needs further investigation to support timely pollution regulation and health protection.