Specificity of projections from wide-field and local motion-processing regions within the middle temporal visual area of the owl monkey
Specificity of projections from wide-field and local motion-processing regions within the middle temporal visual area of the owl monkey
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DOI：
10.1523/jneurosci.20-03-01157.2000
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发表时间：
2000-02-01
影响因子：
5.3
通讯作者：
Born, RT
中科院分区：
文献类型：
--
作者：
Berezovskii, VK;Born, RT
猫头鹰猴的中颞叶视区(MT)在解剖学上是根据偏爱的运动方向和不同类型的中心-周围相互作用来组织的。后者由神经元簇组成，这些神经元的感受野具有对抗性的周围环境，使它们对宽视野运动(局部运动柱)没有反应，这些神经元群的感受野具有附加环境，因此对宽视野运动(宽视野运动柱)反应最好。为了了解这些区域的信息是否保持沿着视觉通路进一步分离，我们将逆行示踪剂注射到MT投射到的两个视觉区域[内侧颞上区(MST)和颞上沟底部(FST)]，然后用2-脱氧葡萄糖标记广野和局部组织。在互补性实验中，我们将顺行示踪剂注射到我们使用微电极记录绘制的MT区域。向MT的背侧FST和腹侧MST标记的细胞团注射集中在宽视野运动柱内，而注射到背侧MST标记的神经元主要在局部运动柱内。顺行示踪实验的结果证实了这些发现。连接的高度特异性加强了MT内广域运动与局部运动处理的功能组织模型。我们的数据支持先前报道的FST分为背侧和腹侧区域的说法，他们还表明，猫头猴的MST与猕猴的MST一样，在局部与宽视野运动处理方面具有功能组织。
The middle temporal visual area (MT) of the owl monkey is anatomically organized with respect to both preferred direction of motion and different types of center-surround interaction. The latter organization consists of clusters of neurons whose receptive fields have antagonistic surrounds that render them unresponsive to wide-field motion (local motion columns) interdigitated with groups of neurons whose receptive fields have additive surrounds and thus respond best to wide-field motion (wide-field motion columns).To learn whether the information in these regions remained segregated further along the visual pathways, we made injections of retrograde tracers into two visual areas to which MT projects [the medial superior temporal area (MST) and fundus of the superior temporal sulcus (FST)] and then labeled the wide-field and local organization using 2-deoxyglucose. In complementary experiments, we injected anterograde tracers into regions of MT that we had mapped using microelectrode recordings.Injections into both dorsal FST and ventral MST labeled clusters of cell bodies in MT that were concentrated within wide-field motion columns, whereas injections into dorsal MST labeled neurons predominantly within local motion columns. Results from the anterograde tracer experiments corroborated these findings. The high degree of specificity in the connections reinforces a model of functional organization for wide-field versus local motion processing within MT. Our data support the previously reported division of FST into separate dorsal and ventral areas, and they also suggest that MST of the owl monkey is, like MST of the macaque, functionally organized with respect to local versus wide-field motion processing.