Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site
Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site
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DOI：
10.1152/ajpregu.2001.281.6.r1862
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发表时间：
2001-12-01
影响因子：
2.8
通讯作者：
Moran, TH
中科院分区：
文献类型：
--
作者：
Aja, S;Sahandy, S;Moran, TH
可卡因和安非他明调节转录物（CART）的肽在注射到侧脑室时减少大鼠的食物摄入。下丘脑和后脑网站的重要控制喂养含有CART免疫反应纤维。为了进一步确定CART的厌食作用的位点，我们比较了在大脑导水管阻塞之前和之后6小时食物剥夺大鼠中对第三或第四心室（3V，4V）CART-（55-102）的进食和其他行为反应。3V CART减少了Ensure的消耗量，并导致在30分钟测试期内观察到的进食和梳理次数减少。这些减少显着减弱导水管阻塞。4V CART抑制了Ensure摄入，并导致在有和没有水管阻断的情况下喂养观察结果减少。3V CART产生了平背姿势和运动相关震颤，这些震颤通过导水管阻塞得以预防。4V CART也产生了这些迹象，无论是否有水管阻塞。我们的结论是，主要hypophagic影响脑室内CART介导的后脑网站。CART诱导的摄食抑制与运动行为改变的相关性质疑了脑室内CART对摄食作用的特异性。
Peptides from cocaine- and amphetamine-regulated transcript (CART) reduce food intake in rats when injected into the lateral ventricle. Hypothalamic and hindbrain sites important in the control of feeding contain CART-immunoreactive fibers. To further define the site of CART's anorectic action, we compared feeding and other behavioral responses to third or fourth ventricular (3V, 4V) CART-(55-102) in 6-h food-deprived rats, both before and after cerebral aqueduct occlusion. 3V CART reduced the volume of Ensure consumed and resulted in fewer observations of eating and grooming within the 30-min test session. These reductions were significantly attenuated by aqueduct obstruction. 4V CART suppressed Ensure intake and resulted in decreased observations of feeding both with and without aqueduct blockade. 3V CART produced flat-backed postures and movement-associated tremors that were prevented by aqueduct obstruction. 4V CART also produced these signs, both with and without aqueduct blockade. We conclude that the major hypophagic effect of intracerebroventricular CART is mediated at a hindbrain site. The association of CART- induced feeding suppression with altered motor behavior questions the specificity of intracerebroventricular CART for actions on feeding.