In vivo 39K, 23Na and 1H MR imaging using a triple resonant RF coil setup
In vivo 39K, 23Na and 1H MR imaging using a triple resonant RF coil setup
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DOI：
10.1016/j.jmr.2009.05.005
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发表时间：
2009-09-01
影响因子：
2.2
通讯作者：
Schad, Lothar R.
中科院分区：
文献类型：
--
作者：
Augath, Mark;Heiler, Patrick;Schad, Lothar R.
维持跨细胞膜的钾离子和钠离子的梯度对于哺乳动物生物体的生理功能是必不可少的。用磁共振成像测量Na-23和K-39的病理变化离子浓度的空间分布提供了在临床诊断中测量组织活力的有前途的方法。现有的研究主要集中在Na-23成像以及光谱学上，只有一项尸检研究用于39 K成像。在本文中，一个三重共振RF线圈设置为大鼠头部在9.4 T的成像的两个核（Na-23和K-39）和采集解剖质子图像在同一实验中不移动的主题或RF线圈。在体内的K-39和Na-23在大鼠大脑的MR图像，以及在同一扫描会话中的解剖质子图像。(C)2009爱思唯尔公司All rights reserved.
The maintenance of a gradient of potassium and sodium ions across the cell membranes is essential for the physiological function of the mammal organism. The measurement of the spatial distribution of pathologically changing ion concentrations of Na-23 and K-39 with magnetic resonance imaging offers a promising approach in clinical diagnostics to measure tissue viability. Existing studies were focused mainly on Na-23 imaging as well as spectroscopy with only one post-mortem study for 39K imaging. In this paper a triple resonant RF coil setup for the rat head at 9.4 T is presented for imaging of both nuclei (Na-23 and K-39) and the acquisition of anatomical proton images in the same experiment without moving the subject or the RF coil. In vivo MR images of K-39 and Na-23 in the rat brain were acquired as well as anatomical proton images in the same scanning session. (C) 2009 Elsevier Inc. All rights reserved.