Effects of digoxin on left ventricular function in coronary artery disease patients.
Effects of digoxin on left ventricular function in coronary artery disease patients.
复制标题
地高辛对冠状动脉疾病患者左心室功能的影响。
DOI：
10.1016/0167-5273(82)90036-5
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发表时间：
1982
影响因子：
3.5
通讯作者：
R. Chahine
中科院分区：
文献类型：
--
作者：
M. Verani;N. Zacca;R. Miller;R. Luchi;R. Chahine
为了评估洋地黄是否能改善或预防急性缺血期间左室射血分数和室壁运动的恶化，我们对15名经血管造影证实的冠心病患者进行了门控血池放射性核素室壁摄影。所有患者均在静息状态和最大仰卧踏车运动状态下，分别于静注地高辛1 mg前和静息后1h进行运动耐量(415±84vs418±107s)、静息室壁运动异常节段数(12vs11)或运动室壁运动节段数(21vs19)比较，差异无统计学意义。10名患者在相同的运动负荷期间发生心绞痛，而不考虑地高辛的使用。12例患者运动时左室射血分数低于运动前，13例运动后左室射血分数低于运动前(P=ns)。静息状态下，地高辛治疗后左室射血分数(53±14%)较治疗前(58±14%)明显升高(P<0.05)。运动中地高辛治疗后左室射血分数无明显改善(50±16%与53±17%，P=ns)，提示急性应用地高辛虽能改善静息状态下的左心功能，但不能提高运动耐量。此外，静脉注射地高辛似乎不能防止运动性缺血时左室壁运动和射血分数的恶化。
To assess whether digitalis modifies or prevents the deterioration of the left ventricular ejection fraction and wall motion during acute ischemia, we performed gated blood pool radionuclide ventriculograms in 15 patients with angiographically documented coronary artery disease. All patients were studied in the resting state and during maximal supine bicycle exercise, both before and 1 hour after 1 mg intravenous digoxin.There was no significant difference, pre-digoxin vs post-digoxin, in exercise tolerance (415 ± 84 vs 418 ± 107 seconds), number of segments with abnormal resting wall motion (12 vs 11) or exercise wall motion (21 vs 19). Ten patients developed angina during the same exercise load, irrespective of digoxin administration. Twelve patients had subnormal left ventricular ejection fraction during exercise pre-digoxin, vs 13 patients post-digoxin (P= ns). In the resting state, the left ventricular ejection fraction was higher after digoxin (53 ± 14% pre vs 58 ± 14% post,P< 0.05). During exercise, however, the left ventricular ejection fraction was not significantly improved after digoxin (50 ± 16% pre vs 53 ± 17% post,P= ns).These data indicate that although acute administration of digoxin improves the resting left ventricular function, it does not improve exercise tolerance to angina. Furthermore, intravenous digoxin does not appear to prevent the deterioration of left ventricular wall motion and ejection fraction during exercise induced ischemia.
长期口服地高辛治疗对缺血性心脏病患者静息和运动高峰时心室功能的影响。
DOI：
10.1016/0002-9149(80)90019-3
发表时间：
1980
期刊：
The American journal of cardiology
影响因子：
--
作者：
Firth,BG;Dehmer,GJ;Corbett,JR;Lewis,SE;Parkey,RW;Willerson,JT
通讯作者：
Willerson,JT