Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
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DOI：
10.1038/nm1467
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发表时间：
2007-01-01
期刊：
影响因子：
82.9
通讯作者：
Cheon, Jinwoo
中科院分区：
文献类型：
--
作者：
Lee, Jae-Hyun;Huh, Yong-Min;Cheon, Jinwoo
成功开发用于检测靶向生物对象的超敏感分子成像纳米探针是一项艰巨的任务。尽管磁性纳米探针有可能发挥这种作用，但目前可用的探针的结果远非最佳。在这里，我们使用人工工程方法来开发创新的磁性纳米探针，该过程涉及对磁性旋转，大小和尖晶石金属铁氧体类型的系统评估。与当前可用的探针相比，这些磁性工程氧化铁（MEIO）纳米探针在与抗体结合时显示出增强的磁共振成像（MRI）敏感性，可检测癌症标志物。另外，我们成功地看到了植入小鼠中的小肿瘤。这种高性能，基于纳米技术的分子探针可以增强可视化对诊断和疗法至关重要的其他生物事件的能力。
Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task. Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal. Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites. These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available. Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.