Hill-Robertson interference in Drosophila melanogaster:: reply to Marais, Mouchiroud and Duret
Hill-Robertson interference in Drosophila melanogaster:: reply to Marais, Mouchiroud and Duret
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DOI：
10.1017/s0016672302006067
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发表时间：
2003-04-01
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影响因子：
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通讯作者：
Hey, J
中科院分区：
文献类型：
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作者：
Kliman, RM;Hey, J
果蝇偏好密码子的使用在重组较低的区域减少。这与群体遗传学理论是一致的，在群体遗传学理论中，对多个目标的选择效果受到连锁引起的随机效应的限制。然而，由于在黑腹葡萄球菌中选择性的偏好密码子以C或G结尾，所以有人认为重组的碱基组成偏向效应可以解释观察到的偏好密码子使用和重组率之间的关系(Marais等人，2003年)。在这里，我们表明碱基组成(蛋白质编码区和内含子区域)和重组率之间的相关性只在后者的较低值下成立。这与Hill-Robertson干扰模型是一致的，并不支持这样一种模型，即重组对密码子使用的整个影响可以归因于它在产生组成偏见方面的潜在作用。
The usage of preferred codons in Drosophila melanogaster is reduced in regions of lower recombination. This is consistent with population genetics theory, whereby the effectiveness of selection on multiple targets is limited by stochastic effects caused by linkage. However, because the selectively preferred codons in D. melanogaster end in C or G, it has been argued that base-composition-biasing effects of recombination can account for the observed relationship between preferred codon usage and recombination rate (Marais et al., 2003). Here, we show that the correlation between base composition (of protein-coding and intron regions) and recombination rate holds only for lower values of the latter. This is consistent with a Hill-Robertson interference model and does not support a model whereby the entire effect of recombination on codon usage can be attributed to its potential role in generating compositional bias.