Circulating irisin levels as a predictive biomarker for sarcopenia: A cross-sectional community-based study
Circulating irisin levels as a predictive biomarker for sarcopenia: A cross-sectional community-based study
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DOI：
10.1111/ggi.13030
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发表时间：
2017-11-01
影响因子：
3.3
通讯作者：
Kong, In Deok
中科院分区：
文献类型：
--
作者：
Chang, Jae Seung;Kim, Tae Ho;Kong, In Deok
AimMyokines 是骨骼肌释放的肽，作为肌少症的潜在生物标志物而广受欢迎。鸢尾素是最近发现的一种肌因子，但其在病理性肌少症中的作用仍不清楚。我们研究了循环鸢尾素水平作为肌肉减少症潜在生物标志物的有效性和准确性。方法我们评估了 715 名社区居住的韩国人的人体测量学、身体成分、肌肉减少症相关参数和血清鸢尾素水平。肌肉减少症的确定是基于亚洲肌肉减少症工作组提出的肌肉萎缩和无力的临床诊断标准。结果循环鸢尾素水平与阑尾肌肉质量/身高(2)（r（男性）= 0.275；r（女性）= 0.321）和握力（r（男性）= 0.219；r（女性）= 0.312）相关。性别（所有 P < 0.01）。此外，肌肉减少症组的平均循环鸢尾素水平低于正常组（均 P < 0.05）。在逻辑回归模型中，即使在调整了性别、年龄和脂肪指数等潜在混杂因素后，血清鸢尾素浓度与肌肉减少症事件之间的关联仍然存在（比值比 0.20，95% CI 0.07-0.60；P 代表趋势）
AimMyokines are peptides released by the skeletal muscle, and have gained popularity as potential biomarkers for sarcopenia. Irisin is a recently identified myokine, but its role in pathological sarcopenia remains unclear. We investigated the validity and accuracy of circulating irisin levels as a potential biomarker for sarcopenia.MethodsWe evaluated the anthropometrics, body composition, sarcopenia-related parameters and serum irisin levels of 715 community-dwelling Koreans. Sarcopenia was determined on the basis of the clinical diagnostic criteria of muscle atrophy and weakness, which were proposed by the Asian Working Group for Sarcopenia.ResultsCirculating irisin levels were correlated with appendicular lean mass/height(2) (r(men) = 0.275; r(women) = 0.321) and handgrip strength (r(men) = 0.219; r(women) = 0.312) in both sexes (all P < 0.01). Furthermore, the mean circulating irisin levels were lower in the sarcopenia group than in the normal group (all P < 0.05). In the logistic regression models, the association between serum irisin concentration and incident sarcopenia persisted even after adjusting for potential confounders, such as sex, age and fat indices (odds ratio 0.20, 95% CI 0.07-0.60; P for trend