Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit
Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit
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DOI：
10.1073/pnas.96.8.4724
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发表时间：
1999-04-13
影响因子：
11.1
通讯作者：
Holzman, PS
中科院分区：
文献类型：
--
作者：
Chen, Y;Nakayama, K;Holzman, PS
精神分裂症患者和他们的许多亲属都表现出平滑追踪眼球追踪受损。这种损伤的大脑机制尚不清楚，但由于伴随着开环加速度和闭环增益的降低，运动信号的感知处理受到影响。先前的一项研究表明，精神分裂症患者的运动辨别力受损。运动辨别可以利用位置和对比度以及速度线索，在这里，我们报告的运动辨别缺陷，这发生在精神分裂症患者和他们的一级亲属，涉及速度检测失败，这出现在判断中间目标速度。在较慢和较快的速度下，速度辨别的判断似乎是正常的，直到我们通过实验将速度线索与非运动线索分开。我们进一步报告说，妥协的速度歧视与缓慢启动顺利的追求。这些发现指向特定的中枢神经系统相关的精神分裂症的病理生理学。
Schizophrenia patients and many of their relatives show impaired smooth pursuit eye tracking. The brain mechanisms underlying this impairment are not yet known, but because reduced open-loop acceleration acid closed-loop gain accompany it, compromised perceptual processing of motion signals is implicated. A previous study showed that motion discrimination is impaired in schizophrenia patients. Motion discrimination can make use of position and contrast as well as velocity cues, Here, we report that the motion discrimination deficit, which occurs in both schizophrenic patients and in their first-degree relatives, involves a failure of velocity detection, which appears when judging intermediate target velocities. At slower and faster velocities, judgments of velocity discrimination seemed normal until we experimentally disentangled velocity cues from nonmotion cues. We further report that compromised velocity discrimination is associated with sluggish initiation of smooth pursuit. These findings point to specific central nervous system correlates of schizophrenic pathophysiology.