A linkage map of the rat genome derived from three F-2 crosses
A linkage map of the rat genome derived from three F-2 crosses
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DOI：
10.1101/gr.7.5.434
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发表时间：
1997-05-01
期刊：
影响因子：
7
通讯作者：
Lathrop, GM
中科院分区：
文献类型：
--
作者：
Bihoreau, MT;Gauguier, D;Lathrop, GM
我们构建了一个包含767个简单序列长度多态性标记的大鼠基因组密集连锁图谱，通过三个高多态性杂交组合，选择WKY x S （n = 159）、BN x S （n = 91）和BN x GK （n = 139）的F-2群体，并对微卫星标记组合进行基因分型。这些位点定义了21个连锁组，分别对应20条大鼠常染色体和X染色体。该图谱跨越了1998厘米的遗传长度。这种组合的连锁图谱应该促进遗传研究的进步，以各种各样的大鼠模型为特征的复杂表型。
We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism, F-2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.