Prognostic Analysis of Patients with Primary Extranodal Lymphoma: A Retrospective Study.
Prognostic Analysis of Patients with Primary Extranodal Lymphoma: A Retrospective Study.
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原发性结外淋巴瘤患者的预后分析：一项回顾性研究
DOI：
10.2147/cmar.s299745
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发表时间：
2021
影响因子：
3.3
通讯作者：
Xu K
中科院分区：
文献类型：
--
作者：
Shen H;Jiang L;Nie L;Fan X;Xu Y;Yin L;Xu L;Xia J;Li Z;Zhu F;Xu K
背景原发于结外器官或组织的原发灶不同，临床表现各异，地域差异显著，各地区缺乏相关报道。患者与方法对220例PEN患者的相关临床及实验室指标进行分析。采用统计学方法分析不同因素对患者总生存期(OS)和无进展生存期(PFS)的影响。结果PNL最常见的3个原发部位是消化系统、头颈部和中枢神经系统。根据患者的风险状况将患者分为低危、中低危、中高危和高危四组，分别计算其3年OS值，其中低危组121例(55%)，3年OS为85.2%(中低危组25.9%，3年OS 66.6%；中高危组15%，3年OS 61.9%；高危组4.09%，3年OS 45.7%)。多因素COX回归分析显示，血清β2-微球蛋白(β-2-MG)和乳酸脱氢酶(LDH)分别是OS和PFS的独立预后因素。功能状态和病理亚型是OS和PFS的独立预后因素。结论β-2-MG、乳酸脱氢酶、运动状态、病理亚型等相关独立危险因素有助于有效判断PENL患者的预后和指导治疗。
Background Originating from extranodal organs or tissues, primary extranodal lymphoma (PENL) acts in different primary sites with diverse clinical performances and PENL has remarkable geographical differences and lacks the relevant reports in each region. Patients and Methods Two hundred and twenty PENL patients were enrolled, and the relevant clinical and laboratory indicators were analyzed. In addition, statistical methods were applied to analyze the effects of different factors on overall survival (OS) and progression-free survival (PFS) of patients. Results The three most frequent primary sites of PENL are the digestive system, head and neck, and central nervous system. The patients were classified into groups based on their risk status, resulting in low-risk, medium-low-risk, medium-high-risk, and high-risk, and their respective 3-year OS values were calculated, which showed that 121 patients (55%) were in the low-risk group and 3-year OS was 85.2% (25.9% medium-low-risk, 3-year OS 66.6%; 15% medium-high-risk, 3-year OS 61.9%; 4.09% high risk, 3-year OS 45.7%). A multivariate analysis of the Cox regression demonstrated that serum beta 2-microglobulin (β2-MG) and lactate dehydrogenase (LDH) were independent prognostic factors for OS and PFS, respectively. Both the performance status and pathological subtypes were independent prognostic factors for OS and PFS. Conclusion The correlated independent risk factors such as β2-MG, LDH, performance status, and pathological subtypes, were helpful for effectively determining the prognosis of PENL patients and guiding treatment.